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KMID : 0816120130160030143
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2013 Volume.16 No. 3 p.143 ~ p.152
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Obesity, Inflammation and Diet
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Lee Hansongyi
Choue Ryo-Won
Lee In-Seok
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Abstract
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Obesity is a state in which there is an over-accumulation of subcutaneous and/or abdominal adipose tissue. This adipose tissue is no longer considered inert and mainly devoted to storing energy; it is emerging as an active tissue in the regulation of physiological and pathological processes, including immunity and inflammation. Adipose tissue produces and releases a variety of adipokines (leptin, adiponectin, resistin, and visfatin), as well as pro- and anti-in-flammatory cytokines (tumor necrosis factor-?, interleukin [IL]-4, IL-6, and others). Adipose tissue is also implicated in the development of chronic metabolic diseases such as type 2 diabetes mellitus or cardiovascular disease. Obesity is thus an underlying condition for inflammatory and metabolic diseases. Diet or dietary patterns play critical roles in obesity and other pathophysiological conditions. A healthy diet and some nutrients are generally considered benefi-cial; however, some dietary nutrients are still considered controversial. In this article, dietary factors that influence inflammation associated with obesity are discussed.
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KEYWORD
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Obesity, Adipose tissue, Inflammation, Diet, Epidemiology, Clinical trial
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